![]() Tests suited for low-throughput settings include immunoblot methods that depend on visualization of bands where patient serum antibodies have bound to gG1 or gG2 antigen immobilised onto membrane strips 16– 17. Commercially available tests can take the form of high throughput assays such as enzyme linked immunosorbant assays (ELISA), also known as enzyme immunoassays (EIA), or automated bead- or luminescence-based assays 15. Glycoprotein G1 (gG1) and glycoprotein G2 (gG2) have proven to be excellent markers for HSV-1 and HSV-2 infection, respectively 14. While the Centers for Disease Control (“CDC” USA) does not consider that serologic screening for HSV-1 and HSV-2 is indicated in the general population, the CDC does recommend that HSV-2 serologic testing be extended to asymptomatic patients who are infected with the AIDS virus, HIV-1, or who are at risk of acquiring HIV-1 13.Īccurate serological testing for HSV is based upon detection of antibodies to the structural glycoprotein G (gG) which can elicit type-specific responses. HSV-2 also increases the risk of transmission of HIV-1 from dually infected persons and can potentiate the progression of HIV disease 11– 12. HSV-2 genital infection also results in a markedly increased risk of acquisition of HIV-1 9– 11. In most cases of neonatal herpes, the mother is unaware of her HSV infection status. Neonatal herpes, an infection acquired in most cases from infants’ mothers during labor and delivery, poses serious risk of long term morbidity with a high risk of later complications, particularly neurodevelopmental 7, 8. Genital herpes is typically subclinical or unrecognized by patients but can also cause considerable morbidity, especially during initial episodes 5, 6. Global incidence is approximately 25 million infections per year with prevalence higher in women than men 4. Herpes Simplex Virus 2 (HSV-2) is a ubiquitous and contagious member of the Herpesviridae family and is the major causative agent of recurrent genital ulcers worldwide 1– 3.
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